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ABSTRACT-Context-The correct diagnosis and effective treatment of Helicobacter pylori gastric infection are essential in controlling this infection. Objective-To Compare the diagnostic value of three tests based in endoscopic gastric biopsies histopathological evaluation with Hematoxylin-Eosin (H-E) staining, testing rapid test and microbiological culture for know Helicobacter pylori active infection, in order To make recommendations for daily clinical practice. Methods-Gastric biopsies from 115 adult patients (85 female/30 male) were obtained by upper gastrointestinal endoscopy and studied by histopathological evaluation with H-E (Antrum-corpus), testing test in 2 hours (antrum) and microbiological culture (antrum). Results-Helicobacter pylori active infection was diagnosed in 67% of patients. Helicobacter pylori active infection was detected by histopathological evaluation with H-E, testing test and microbiological culture in 87%, 79% and 70% of the positive cases, respectively. There were significant differences when histopathological evaluation with H-E and testing test rapid test when compared with microbiological test (P
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